benaGene has been designed to modify metabolism to mimic calorie restricted conditions at the cellular level--without the usual reduction in calorie content.  It does this by providing Thermally Stabilized Oxaloacetate (a human metabolite) to modify the NAD+/NADH ratio.  The NAD+/NADH ratio is increased by using a biological diode interaction with the mitochondria.  The increased ratio (when held for a minimum of at least a 2.5 week period) acts as a switching sensor that causes the cells to produce a series of beneficial proteins from DNA genes that are typically silenced in normal metabolism. 

benaGene works on several levels to reduce the effects of aging:

• The proteins expressed by the genes are "turned back" to a younger profile. This same profile is seen by calorie restricted animals, and increases lifespan and heath span by 20 to 40% in laboratory tests.  See More.
• Blood glucose levels are reduced.  This results in lower Advanced Glycation End-products (AGEs) because there are lower glucose levels overall to react with the proteins. See More. 
• Weight levels are dropped, resulting in lower risk factors for diabetes, heart disease and other weight related illness. See More.
• benaGene acts as a powerful anti-oxidant to reduce cellular damage from free radicals.
• benaGene increases the rate of gluconeogenesis, which increases protein turn-over in the cells.  Regeneration of cellular proteins reduces damaged cross-link protein accumulation.
• Finally, benaGene promotes an increase in DNA repair

As a consequence of these changes, the results are revolutionary:

• Life Extension & Increased Heath Span
• C57Bl/6 mice live 25% longer on a benaGene supplemented diet
• mice supplemented with benaGene show less age related disease including inflammation, curvature of the spine, graying of fur
• The increase in remaining lifespan (from the date benaGene supplementation was started) is 40% in mice
• Drosophila melanogaster (fruit flys) live 20% longer on a benaGene supplemented diet
• Weight Management
• C57Bl/6 mice given benaGene gain less weight than control groups when fed an unrestricted diet
• Genomic Changes
• Proteins upregulated and down-regulated mimic a calorie restricted profile (98.1% directional correlation in mouse liver tissue) after 21 weeks of use
• Glucose Reduction
• Clinical human trials on benaGene ingredients show an average reduction in fasting glucose levels of 25% in Type I and Type II diabetics
• Glucose uptake on both diabetic and non-diabetic humans is increased at the cellular level 
• Anti-Oxidant Protection
• Retinal, Pancreatic and Neural Tissues have all been shown to be protected by benaGene